Executive Director, Pharmacometrics Head
Company: Takeda
Location: Boston
Posted on: January 10, 2026
|
|
|
Job Description:
By clicking the “Apply” button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda’s Privacy Notice and Terms of Use . I further attest
that all information I submit in my employment application is true
to the best of my knowledge. Job Description Objective / Purpose:
Takeda is a global, values-based, R&D-driven, top 10
biopharmaceutical leader committed to discover and deliver
life-transforming treatments, guided by our commitment to patients,
our people and the planet. Our Data and Quantitative Sciences
Department (DQS) is made up of more than 700 quantitative
scientists who harness the insight of data to speed the development
of highly innovative treatments to patients. The scientists (from
pharmacometrics, quantitative clinical pharmacology, DMPK&M,
Translational biomarkers and bioanalysis (TB&B), Imaging,
statistics, programming, outcomes research and epidemiology,
patient safety & pharmacovigilance) bring their expertise to our
global program teams and reimagine our disciplines. They work with
novel data streams, including real-world data and digital tools,
and apply advanced analytics including artificial intelligence and
automation. As part of DQS and Quantitative Pharmacology and
Translational Science (QPTS), the Pharmacometrics team is a
therapeutically agnostic team driving, implementing and executing
an MIDD strategy for each asset from pre-FIH through life-cycle
management within the global project team. Position Objectives :
Strategically leads and drives the implementation of model-informed
drug development strategies across the early and late phase
clinical portfolio to enable robust dose/regimen recommendations,
trial designs, and go-no-go decisions through the life-cycle of our
products in collaboration with other functions (e.g. QCP, SQS,
GEO). Drives the implementation of automation and the use of AI in
the discipline of pharmacometrics (E2E) to enable increased
capacity, quality and timeline efficiencies. By being integrated
into the AI eco-system, you will be constantly driving the
advancement of the field and enabler of data and model-based
decision making across all phases of drug development. Is a
recognized expert internally and externally in the field of
mechanistic modelling and more traditional pharmacometrics with
demonstrated experience optimizing clinical drug development.
Demonstrated expertise in applying MIDD principles to emerging data
sources (RWD, natural history registries, omics data, HER data,
etc.) to fully inform development programs. Explores and excels in
synergistic relationships with experts and leaders in statistics,
and other key data science disciplines driving and integrated
approach. Provides additional portfolio support through program
reviews, collaborative decision-making, infrastructure and best
practice initiatives. Experience in applying quantitative
approaches to evaluation of probability of technical success,
including evaluating business development opportunities. Serves as
an ambassador of Pharmacometrics, Quantitative Clinical
Pharmacology (QCP), QPTS and DQS to the R&D organization and
the external scientific community through high-value participation
at scientific meetings and impactful publications.
Accountabilities: Leads and drives a team of in-house
pharmacometricians to deliver all pharmacometrics analyses
internally and externally to support the Takeda clinical portfolio
and Business development activities. Maintains a network and strong
relationship with external vendors to support regulatory
pharmacometrics analyses Operates at an enterprise level, defines,
leads and drives cross therapeutic area and platform level
pharmacometrics strategies with the aim of driving the advancement
of the Takeda portfolio through various decision-making milestones.
Seeks opportunities to extend MIDD based approaches beyond drug
development to decisions impacting product valuation and
reimbursement. Leads and Drives the evolution of our in-house
modelling platform capabilities with a vision of increased
automation, integration of emerging data sources in addition to
program-level clinical trial data, and use of AI with an end-to-end
mindset and process, in compliance with GxP. Works with colleagues
in DMPK&M to enable the transition and implementation of
mechanistic modelling and thinking (PK-PD, PBPK-PD, QSP) into the
clinical portfolio as an assets progress through IND, with the aim
of enriching our understanding and potential opportunities,
populations, dosing, trial design optimization. Key driver of
pharmacometrics strategies, including Model-Informed Drug
Development (MIDD) as part of the overall QDM framework integrating
pharmacometrics plan in collaboration with QCP and SQS. Represents
Pharmacometrics, where required in global or regional regulatory
agency meetings and be responsible for the technical component of
the clinical pharmacology summary documents for regulatory
submissions. Maintains a high standard for good clinical practice,
compliance, and ethics. Participates as a member of Business
Development due diligence, and provides fir-for-purpose evidence
based risk assessments to the team in a timely manner. Promotes and
drives the Pharmacometrics vision and mission, identifying
opportunities and creates delivery for DQS mission to make R&D
business impact. Seen as a role model to member of QCP and DQS.
Acts as a cross functional and collaborative leader Demonstrates
leadership in scientific societies and cross-industry consortiums
related to the pharmacometrics work streams within ACCP, ASCPT,
ACOP, PAGE, ISQP, IQ, and DIA. Education & Competencies (Technical
and Behavioral): Desired education qualifications and equivalencies
and desired minimum years industry experience: Pharm D. or PhD with
15 years of working experience in a quantitative field with
extensive in pharmacometrics, mechanistic modelling, statistics or
chemical bio-engineering with extensive management and leadership
experience. MS with 18 years' working experience in a quantitative
field with extensive experience in pharmacometrics, mechanistic
modelling, statistics or chemical bio-engineering with extensive
management and leadership experience. Desired technical skills:
Established Subject Matter Expert in multiple areas internally or
externally including leadership of one or more internal or external
focus groups. Robust understanding of pharmacology and statistical
principles Recognized expert internally and externally in the area
of pharmacometrics and clinical pharmacology and its criticality in
all stages of drug development. Demonstrated passion for innovative
applications and technologies, including AI and automation. Defines
and leads a cross-therapeutic strategy, directing and overseeing
complex pharmacometrics analyses including developing innovative
methodology/ in close partnership with other DQS functions and
other internal and/or external partners. Drives innovative
strategies and influences business-critical decision-making beyond
QCP/Pharmacometrics responsibilities. Solid mathematical and
pharmacological/mechanistic background and training. Experienced
drug developer with a significant understanding of R&D cross
functional strategy from candidate selection through life-cycle
management. Significant experience in HA interactions and
submissions. Extensive experience in the implementation of MIDD
strategies as part of global filings and approvals. Drives for
efficiency and cost effectiveness in drug development plan by
implementation of a robust pharmacometrics plan to optimize trial
design, sample size, decisions, timepoints of assessment using
innovative processes and methodologies or by building internal
capabilities. Ability to evaluate benefit-risk associated with
project/asset/franchise and TAU decisions and effectively manage
GPT expectations. The ability to establish external networks to
facilitate collaborations across industry, government, and
academia. Desired behavioral competencies: Provides strong
scientific and strategic leadership. Experienced people
manager/leader Strong organizational skills in terms of process and
resources. Good communicator on an inter-personal basis as well as
in an audience Mobilizes high performance teams. Influences beyond
QPTS and DQS. Effective communication including influencing others,
negotiation skills, and able to manage conflicts in matrix
cross-functional teams Prioritizes and delegates. Energizes the
organization and prepares for the future. More about us: At Takeda,
we are transforming patient care through the development of novel
specialty pharmaceuticals and best in class patient support
programs. Takeda is a patient-focused company that will inspire and
empower you to grow through life-changing work. Certified as a
Global Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the world. This position is
currently classified as "hybrid" following Takeda's Hybrid and
Remote Work policy. Takeda Compensation and Benefits Summary We
understand compensation is an important factor as you consider the
next step in your career. We are committed to equitable pay for all
employees, and we strive to be more transparent with our pay
practices. For Location: Boston, MA U.S. Base Salary Range:
$208,200.00 - $327,140.00 The estimated salary range reflects an
anticipated range for this position. The actual base salary offered
may depend on a variety of factors, including the qualifications of
the individual applicant for the position, years of relevant
experience, specific and unique skills, level of education
attained, certifications or other professional licenses held, and
the location in which the applicant lives and/or from which they
will be performing the job. The actual base salary offered will be
in accordance with state or local minimum wage requirements for the
job location. U.S. based employees may be eligible for short-term
and/ or long-term incentives. U.S. based employees may be eligible
to participate in medical, dental, vision insurance, a 401(k) plan
and company match, short-term and long-term disability coverage,
basic life insurance, a tuition reimbursement program, paid
volunteer time off, company holidays, and well-being benefits,
among others. U.S. based employees are also eligible to receive,
per calendar year, up to 80 hours of sick time, and new hires are
eligible to accrue up to 120 hours of paid vacation. EEO Statement
Takeda is proud in its commitment to creating a diverse workforce
and providing equal employment opportunities to all employees and
applicants for employment without regard to race, color, religion,
sex, sexual orientation, gender identity, gender expression,
parental status, national origin, age, disability, citizenship
status, genetic information or characteristics, marital status,
status as a Vietnam era veteran, special disabled veteran, or other
protected veteran in accordance with applicable federal, state and
local laws, and any other characteristic protected by law.
Locations Boston, MA Worker Type Employee Worker Sub-Type Regular
Time Type Full time Job Exempt Yes It is unlawful in Massachusetts
to require or administer a lie detector test as a condition of
employment or continued employment. An employer who violates this
law shall be subject to criminal penalties and civil liability.
Keywords: Takeda, Hartford , Executive Director, Pharmacometrics Head, Science, Research & Development , Boston, Connecticut
